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The tumor microenvironment in breast cancer is often characterized by regions of low oxygen tension, arising as a result of rapid tumor growth that outpaces the formation of new blood vessels (angiogenesis)

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Other clinical applications of methylene blue include improvement of hypotension associated with various clinical states, an antiseptic in urinary tract infections, treatment of hypoxia and hyperdynamic circulation in cirrhosis of liver and severe hepatopulmonary syndrome, and treatment of ifofosamide induced neurotoxicity